Transcription factors with Perturb-seq knockdown data for DEXI. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DEXI upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DEXI, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:10,743,473–10,744,692 | 198.3 kb | Distal (>10kb) Multiome | 1045 | |
| chr16:10,818,333–10,818,889 | 123.9 kb | Distal (>10kb) Multiome | 127 | |
| chr16:10,942,009–10,942,939 | 53 bp | At TSS Multiome | 627 | |
| chr16:10,944,257–10,944,954 | 2.0 kb | Proximal (<10kb) Multiome | 887 | |
| chr16:10,949,449–10,949,898 | 7.0 kb | Proximal (<10kb) | 184 | |
| chr16:11,032,660–11,033,355 | 90.6 kb | Distal (>10kb) Multiome | 81 | |
| chr16:11,104,839–11,105,431 | 162.7 kb | Distal (>10kb) Multiome | 471 | |
| chr16:11,254,519–11,257,585 | 313.7 kb | Distal (>10kb) Multiome HiCAR | 1111 |
Genomic view of the DEXI locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.