Enables identical protein binding activity. Predicted to be involved in centriole replication and de novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Predicted to be located in cytoplasm and membrane. Predicted to be active in centriole and deuterosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DEUP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DEUP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DEUP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:93,116,571–93,117,518 | 213.8 kb | Distal (>10kb) Multiome | 130 | |
| chr11:93,197,175–93,198,389 | 132.6 kb | Distal (>10kb) Multiome | 883 | |
| chr11:93,330,006–93,331,029 | 5 bp | At TSS Multiome | 319 | |
| chr11:93,444,389–93,445,160 | 114.2 kb | Distal (>10kb) Multiome | 173 | |
| chr11:93,542,187–93,543,870 | 212.8 kb | Distal (>10kb) Multiome | 790 |
Genomic view of the DEUP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.