Enables importin-alpha family protein binding activity and long-chain fatty acyl-CoA hydrolase activity. Involved in protein export from nucleus and regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytosol. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DESI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DESI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DESI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:41,380,458–41,382,737 | 239.3 kb | Distal (>10kb) Multiome | 925 | |
| chr22:41,413,486–41,414,305 | 207.2 kb | Distal (>10kb) Multiome | 832 | |
| chr22:41,444,084–41,445,743 | 176.5 kb | Distal (>10kb) Multiome | 607 | |
| chr22:41,446,165–41,449,007 | 174.1 kb | Distal (>10kb) Multiome | 1188 | |
| chr22:41,468,341–41,469,602 | 152.1 kb | Distal (>10kb) Multiome | 920 | |
| chr22:41,512,659–41,513,151 | 108.0 kb | Distal (>10kb) Multiome | 354 | |
| chr22:41,543,855–41,544,782 | 76.5 kb | Distal (>10kb) Multiome | 755 | |
| chr22:41,589,188–41,590,530 | 31.1 kb | Distal (>10kb) Multiome | 758 | |
| chr22:41,620,173–41,622,049 | 91 bp | At TSS Multiome | 880 | |
| chr22:41,666,496–41,667,405 | 45.8 kb | Distal (>10kb) Multiome | 725 | |
| chr22:41,697,169–41,697,792 | 76.3 kb | Distal (>10kb) Multiome | 464 | |
| chr22:41,800,274–41,801,345 | 179.6 kb | Distal (>10kb) Multiome | 816 | |
| chr22:41,832,291–41,834,215 | 211.9 kb | Distal (>10kb) Multiome | 1023 | |
| chr22:41,845,927–41,846,489 | 225.1 kb | Distal (>10kb) Multiome | 271 | |
| chr22:41,909,821–41,910,788 | 289.2 kb | Distal (>10kb) Multiome | 251 | |
| chr22:41,913,915–41,914,497 | 293.1 kb | Distal (>10kb) Multiome | 143 | |
| chr22:41,914,624–41,915,454 | 294.0 kb | Distal (>10kb) Multiome | 273 | |
| chr22:41,919,501–41,920,436 | 298.9 kb | Distal (>10kb) Multiome | 337 |
Genomic view of the DESI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.