The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for DERL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DERL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DERL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:23,716,825–23,717,722 | 121.6 kb | Distal (>10kb) Multiome | 846 | |
| chr22:23,750,563–23,751,795 | 87.9 kb | Distal (>10kb) Multiome | 687 | |
| chr22:23,767,199–23,768,799 | 70.8 kb | Distal (>10kb) Multiome | 812 | |
| chr22:23,772,486–23,773,491 | 66.2 kb | Distal (>10kb) Multiome | 415 | |
| chr22:23,786,359–23,787,793 | 51.8 kb | Distal (>10kb) Multiome | 723 | |
| chr22:23,838,611–23,839,672 | 185 bp | At TSS Multiome | 472 | |
| chr22:23,849,291–23,849,993 | 10.7 kb | Distal (>10kb) Multiome | 577 | |
| chr22:23,856,822–23,858,514 | 18.8 kb | Distal (>10kb) Multiome | 735 | |
| chr22:23,893,788–23,895,770 | 55.3 kb | Distal (>10kb) Multiome | 932 | |
| chr22:23,913,645–23,914,284 | 75.0 kb | Distal (>10kb) Multiome | 787 | |
| chr22:23,956,273–23,956,867 | 117.5 kb | Distal (>10kb) Multiome | 182 | |
| chr22:24,010,924–24,011,936 | 172.3 kb | Distal (>10kb) Multiome | 796 |
Genomic view of the DERL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.