Enables guanyl-nucleotide exchange factor activity. Predicted to be located in cytosol. Predicted to be active in recycling endosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DENND6B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DENND6B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DENND6B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:50,030,288–50,030,739 | 296.6 kb | Distal (>10kb) Multiome | 433 | |
| chr22:50,169,918–50,170,446 | 156.8 kb | Distal (>10kb) Multiome | 245 | |
| chr22:50,184,288–50,186,776 | 141.1 kb | Distal (>10kb) Multiome | 542 | |
| chr22:50,199,706–50,201,679 | 126.0 kb | Distal (>10kb) Multiome | 612 | |
| chr22:50,244,340–50,245,635 | 81.9 kb | Distal (>10kb) Multiome | 868 | |
| chr22:50,250,480–50,251,917 | 75.6 kb | Distal (>10kb) Multiome HiCAR | 683 | |
| chr22:50,261,070–50,261,932 | 65.3 kb | Distal (>10kb) Multiome | 512 | |
| chr22:50,267,469–50,268,208 | 59.3 kb | Distal (>10kb) Multiome | 196 | |
| chr22:50,271,717–50,272,193 | 55.0 kb | Distal (>10kb) Multiome | 331 | |
| chr22:50,299,702–50,300,750 | 26.6 kb | Distal (>10kb) Multiome | 250 | |
| chr22:50,307,140–50,307,760 | 19.4 kb | Distal (>10kb) Multiome | 392 | |
| chr22:50,326,615–50,327,631 | 112 bp | At TSS Multiome | 754 | |
| chr22:50,342,153–50,342,608 | 15.5 kb | Distal (>10kb) Multiome | 553 | |
| chr22:50,342,772–50,343,603 | 16.2 kb | Distal (>10kb) Multiome | 573 | |
| chr22:50,474,348–50,475,571 | 148.1 kb | Distal (>10kb) Multiome | 487 | |
| chr22:50,481,062–50,482,150 | 154.5 kb | Distal (>10kb) Multiome | 387 | |
| chr22:50,506,343–50,508,710 | 181.0 kb | Distal (>10kb) Multiome | 856 | |
| chr22:50,524,965–50,527,480 | 200.1 kb | Distal (>10kb) Multiome | 1031 | |
| chr22:50,529,065–50,532,692 | 203.9 kb | Distal (>10kb) Multiome | 745 | |
| chr22:50,562,609–50,563,508 | 236.0 kb | Distal (>10kb) Multiome | 680 | |
| chr22:50,582,134–50,583,431 | 255.9 kb | Distal (>10kb) Multiome | 871 |
Genomic view of the DENND6B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.