Enables guanyl-nucleotide exchange factor activity. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DENND2D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DENND2D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DENND2D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:111,197,597–111,198,008 | 6.5 kb | Proximal (<10kb) | 113 | |
| chr1:111,202,847–111,203,091 | 1.4 kb | Proximal (<10kb) | 125 | |
| chr1:111,203,689–111,204,663 | at TSS | At TSS | 352 | |
| chr1:111,214,517–111,214,955 | 10.0 kb | Proximal (<10kb) | 122 |
Genomic view of the DENND2D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.