DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. [provided by RefSeq, Apr 2011]
Transcription factors with Perturb-seq knockdown data for DDX17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DDX17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DDX17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:38,214,397–38,215,017 | 291.5 kb | Distal (>10kb) Multiome | 382 | |
| chr22:38,272,379–38,273,237 | 233.4 kb | Distal (>10kb) Multiome | 526 | |
| chr22:38,317,171–38,317,940 | 188.9 kb | Distal (>10kb) Multiome | 524 | |
| chr22:38,319,024–38,319,874 | 186.8 kb | Distal (>10kb) Multiome | 181 | |
| chr22:38,335,940–38,336,726 | 170.1 kb | Distal (>10kb) Multiome | 297 | |
| chr22:38,353,217–38,354,166 | 152.9 kb | Distal (>10kb) Multiome | 404 | |
| chr22:38,397,757–38,399,352 | 107.4 kb | Distal (>10kb) Multiome | 345 | |
| chr22:38,455,555–38,456,345 | 50.3 kb | Distal (>10kb) Multiome | 403 | |
| chr22:38,461,291–38,461,848 | 44.7 kb | Distal (>10kb) Multiome | 595 | |
| chr22:38,504,707–38,505,172 | 1.2 kb | Proximal (<10kb) | 321 | |
| chr22:38,505,466–38,506,961 | 165 bp | At TSS Multiome | 889 | |
| chr22:38,569,664–38,571,256 | 64.0 kb | Distal (>10kb) Multiome | 559 | |
| chr22:38,655,982–38,657,104 | 150.1 kb | Distal (>10kb) Multiome | 698 | |
| chr22:38,681,730–38,682,262 | 175.6 kb | Distal (>10kb) Multiome | 947 | |
| chr22:38,700,377–38,701,744 | 194.6 kb | Distal (>10kb) Multiome | 916 | |
| chr22:38,705,151–38,706,595 | 199.4 kb | Distal (>10kb) Multiome | 821 | |
| chr22:38,755,428–38,756,383 | 249.7 kb | Distal (>10kb) Multiome | 770 | |
| chr22:38,793,674–38,794,378 | 287.8 kb | Distal (>10kb) Multiome | 484 |
Genomic view of the DDX17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.