DDT

D-dopachrome tautomerase | D-DT, DDCT, MIF-2, MIF2

D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008]

Member of: DE-1

Biological processes 16 terms

D-dopachrome decarboxylase activity (GO:0033981)D-dopachrome decarboxylase activity (GO:0033981)D-dopachrome decarboxylase activity (GO:0033981)cytokine receptor binding (GO:0005126)cytoplasm (GO:0005737)cytoplasm (GO:0005737)dopachrome isomerase activity (GO:0004167)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)negative regulation of macrophage chemotaxis (GO:0010760)phenylpyruvate tautomerase activity (GO:0050178)phenylpyruvate tautomerase activity (GO:0050178)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of inflammatory response (GO:0050729)positive regulation of tumor necrosis factor production (GO:0032760)

Expression (TPM)

TFs regulating DDT 0 TFs

Transcription factors with Perturb-seq knockdown data for DDT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DDT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DDT

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DDT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr22:23,716,825–23,717,722	255.8 kb	Distal (>10kb) Multiome	846
chr22:23,750,563–23,751,795	222.1 kb	Distal (>10kb) Multiome HiCAR	687
chr22:23,767,199–23,768,799	205.0 kb	Distal (>10kb) Multiome	812
chr22:23,772,486–23,773,491	200.3 kb	Distal (>10kb) Multiome	415
chr22:23,786,359–23,787,793	185.9 kb	Distal (>10kb) Multiome	723
chr22:23,789,208–23,789,944	183.8 kb	Distal (>10kb) Multiome	146
chr22:23,804,750–23,805,326	168.2 kb	Distal (>10kb) Multiome	44
chr22:23,838,611–23,839,672	134.0 kb	Distal (>10kb) Multiome	472
chr22:23,849,291–23,849,993	123.5 kb	Distal (>10kb) Multiome	577
chr22:23,856,822–23,858,514	115.4 kb	Distal (>10kb) Multiome	735
chr22:23,893,788–23,895,770	77.6 kb	Distal (>10kb) Multiome HiCAR	932
chr22:23,913,645–23,914,284	59.1 kb	Distal (>10kb) Multiome HiCAR	787
chr22:23,956,273–23,956,867	16.6 kb	Distal (>10kb) Multiome HiCAR	182
chr22:24,010,924–24,011,936	38.1 kb	Distal (>10kb) Multiome	796
chr22:24,155,850–24,157,427	183.9 kb	Distal (>10kb) Multiome HiCAR	647
chr22:24,270,283–24,271,594	297.7 kb	Distal (>10kb) Multiome HiCAR	875
chr22:24,554,481–24,556,186	582.1 kb	Distal (>10kb) Multiome HiCAR	1058

Genome Browser

Genomic view of the DDT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.