DDR2
discoidin domain receptor tyrosine kinase 2 | TKT, NTRKR3, TYRO10

This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]

Biological processes 67 terms
ATP binding (GO:0005524)apical plasma membrane (GO:0016324)biomineral tissue development (GO:0031214)biomineral tissue development (GO:0031214)cell adhesion (GO:0007155)cell surface receptor protein tyrosine kinase signaling pathway (GO:0007169)cell surface receptor protein tyrosine kinase signaling pathway (GO:0007169)cellular response to angiotensin (GO:1904385)cellular response to hypoxia (GO:0071456)cellular response to transforming growth factor beta stimulus (GO:0071560)chondrocyte proliferation (GO:0035988)chondrocyte proliferation (GO:0035988)chondrocyte proliferation (GO:0035988)collagen binding (GO:0005518)collagen binding (GO:0005518)collagen binding (GO:0005518)collagen fibril organization (GO:0030199)collagen fibril organization (GO:0030199)collagen-activated tyrosine kinase receptor signaling pathway (GO:0038063)collagen-activated tyrosine kinase receptor signaling pathway (GO:0038063)endochondral bone growth (GO:0003416)endochondral bone growth (GO:0003416)focal adhesion (GO:0005925)membrane (GO:0016020)negative regulation of apoptotic process (GO:0043066)negative regulation of hydrogen peroxide-mediated programmed cell death (GO:1901299)peptidyl-tyrosine phosphorylation (GO:0018108)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)positive regulation of collagen biosynthetic process (GO:0032967)positive regulation of extracellular matrix disassembly (GO:0090091)positive regulation of extracellular matrix disassembly (GO:0090091)positive regulation of fibroblast migration (GO:0010763)positive regulation of fibroblast migration (GO:0010763)positive regulation of fibroblast migration (GO:0010763)positive regulation of fibroblast proliferation (GO:0048146)positive regulation of fibroblast proliferation (GO:0048146)positive regulation of hepatic stellate cell activation (GO:2000491)positive regulation of hepatic stellate cell proliferation (GO:1904899)positive regulation of neuron projection development (GO:0010976)positive regulation of osteoblast differentiation (GO:0045669)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)positive regulation of protein kinase activity (GO:0045860)positive regulation of vascular associated smooth muscle cell migration (GO:1904754)positive regulation of vascular associated smooth muscle cell proliferation (GO:1904707)positive regulation of wound healing (GO:0090303)protein autophosphorylation (GO:0046777)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein tyrosine kinase activity (GO:0004713)protein tyrosine kinase collagen receptor activity (GO:0038062)protein tyrosine kinase collagen receptor activity (GO:0038062)protein tyrosine kinase collagen receptor activity (GO:0038062)regulation of bone mineralization (GO:0030500)regulation of extracellular matrix disassembly (GO:0010715)regulation of extracellular matrix disassembly (GO:0010715)regulation of tissue remodeling (GO:0034103)response to muscle stretch (GO:0035994)signal transduction (GO:0007165)signaling receptor complex (GO:0043235)transmembrane receptor protein tyrosine kinase activity (GO:0004714)transmembrane receptor protein tyrosine kinase activity (GO:0004714)transmembrane receptor protein tyrosine kinase activity (GO:0004714)
Expression (TPM)
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