DDA1

DET1 and DDB1 associated 1 | MGC2594, PCIA1, C19orf58

Involved in protein polyubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1

Biological processes 9 terms

Cul4-RING E3 ubiquitin ligase complex (GO:0080008)Cul4-RING E3 ubiquitin ligase complex (GO:0080008)nucleoplasm (GO:0005654)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)protein binding (GO:0005515)protein polyubiquitination (GO:0000209)protein ubiquitination (GO:0016567)regulation of natural killer cell activation (GO:0032814)regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)

Expression (TPM)

TFs regulating DDA1 0 TFs

Transcription factors with Perturb-seq knockdown data for DDA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DDA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DDA1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DDA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:17,074,934–17,076,532	234.0 kb	Distal (>10kb) Multiome	890
chr19:17,209,430–17,210,427	99.7 kb	Distal (>10kb) Multiome	245
chr19:17,215,005–17,215,979	94.1 kb	Distal (>10kb) Multiome	897
chr19:17,225,705–17,226,889	83.2 kb	Distal (>10kb) Multiome	870
chr19:17,234,748–17,236,650	73.7 kb	Distal (>10kb) Multiome	612
chr19:17,244,882–17,247,104	63.4 kb	Distal (>10kb) Multiome	862
chr19:17,247,935–17,248,860	61.0 kb	Distal (>10kb) Multiome	588
chr19:17,266,931–17,267,755	42.3 kb	Distal (>10kb) Multiome	720
chr19:17,281,537–17,283,120	26.7 kb	Distal (>10kb) Multiome	669
chr19:17,292,242–17,293,049	16.9 kb	Distal (>10kb) Multiome	513
chr19:17,302,721–17,303,771	6.1 kb	Proximal (<10kb) Multiome	636
chr19:17,305,286–17,306,514	3.9 kb	Proximal (<10kb) Multiome	947
chr19:17,309,159–17,310,151	42 bp	At TSS Multiome	741
chr19:17,327,532–17,329,548	18.4 kb	Distal (>10kb) Multiome	370
chr19:17,334,287–17,335,052	25.2 kb	Distal (>10kb) Multiome	870
chr19:17,336,574–17,338,240	27.9 kb	Distal (>10kb) Multiome	924
chr19:17,340,311–17,341,226	31.1 kb	Distal (>10kb) Multiome	419
chr19:17,390,414–17,391,521	81.6 kb	Distal (>10kb) Multiome	615
chr19:17,394,998–17,395,433	85.7 kb	Distal (>10kb) Multiome	403
chr19:17,398,863–17,399,537	89.6 kb	Distal (>10kb) Multiome	132
chr19:17,403,087–17,404,355	94.0 kb	Distal (>10kb) Multiome	211
chr19:17,419,503–17,420,821	110.4 kb	Distal (>10kb) Multiome	869
chr19:17,424,865–17,425,411	115.6 kb	Distal (>10kb) Multiome	328
chr19:17,448,174–17,448,841	139.1 kb	Distal (>10kb) Multiome	392
chr19:17,468,858–17,470,905	160.6 kb	Distal (>10kb) Multiome	743
chr19:17,488,739–17,489,689	179.6 kb	Distal (>10kb) Multiome	381
chr19:17,511,113–17,512,592	202.0 kb	Distal (>10kb) Multiome	1021
chr19:17,538,878–17,540,353	230.2 kb	Distal (>10kb) Multiome	725
chr19:17,555,194–17,556,523	246.0 kb	Distal (>10kb) Multiome	713
chr19:17,576,463–17,577,455	267.4 kb	Distal (>10kb) Multiome	236
chr19:17,579,580–17,580,242	270.4 kb	Distal (>10kb) Multiome	281
chr19:17,605,468–17,607,009	296.6 kb	Distal (>10kb) Multiome	1030

Genome Browser

Genomic view of the DDA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.