The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for DCXR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCXR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCXR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,832,473–81,833,976 | 204.1 kb | Distal (>10kb) Multiome | 1015 | |
| chr17:81,859,762–81,861,595 | 176.5 kb | Distal (>10kb) Multiome | 1134 | |
| chr17:81,868,421–81,868,978 | 168.8 kb | Distal (>10kb) Multiome | 577 | |
| chr17:81,869,000–81,872,289 | 166.1 kb | Distal (>10kb) Multiome | 1136 | |
| chr17:81,891,143–81,892,257 | 145.6 kb | Distal (>10kb) Multiome | 969 | |
| chr17:81,910,443–81,911,980 | 125.8 kb | Distal (>10kb) Multiome | 806 | |
| chr17:81,917,586–81,918,522 | 119.2 kb | Distal (>10kb) Multiome | 619 | |
| chr17:81,923,285–81,923,863 | 113.8 kb | Distal (>10kb) Multiome | 399 | |
| chr17:81,926,141–81,929,133 | 109.5 kb | Distal (>10kb) Multiome | 1034 | |
| chr17:81,936,855–81,937,682 | 100.0 kb | Distal (>10kb) Multiome | 854 | |
| chr17:81,959,299–81,962,169 | 77.6 kb | Distal (>10kb) Multiome | 805 | |
| chr17:81,966,804–81,968,359 | 69.3 kb | Distal (>10kb) Multiome | 908 | |
| chr17:81,976,595–81,978,312 | 59.7 kb | Distal (>10kb) Multiome | 1001 | |
| chr17:82,019,856–82,020,391 | 17.2 kb | Distal (>10kb) Multiome | 436 | |
| chr17:82,022,355–82,024,111 | 14.3 kb | Distal (>10kb) Multiome | 898 | |
| chr17:82,029,976–82,032,662 | 5.4 kb | Proximal (<10kb) Multiome | 695 | |
| chr17:82,036,902–82,037,961 | 272 bp | At TSS Multiome | 892 | |
| chr17:82,051,387–82,052,184 | 14.4 kb | Distal (>10kb) Multiome | 479 | |
| chr17:82,065,558–82,066,150 | 28.5 kb | Distal (>10kb) Multiome | 967 | |
| chr17:82,096,478–82,100,203 | 61.2 kb | Distal (>10kb) Multiome | 1085 | |
| chr17:82,103,334–82,104,356 | 66.2 kb | Distal (>10kb) Multiome | 672 | |
| chr17:82,212,405–82,213,592 | 175.5 kb | Distal (>10kb) Multiome | 911 | |
| chr17:82,228,266–82,232,536 | 191.6 kb | Distal (>10kb) Multiome | 1048 | |
| chr17:82,272,608–82,274,062 | 236.3 kb | Distal (>10kb) Multiome | 943 | |
| chr17:82,278,488–82,279,226 | 241.6 kb | Distal (>10kb) Multiome | 229 | |
| chr17:82,292,400–82,293,256 | 255.6 kb | Distal (>10kb) Multiome | 944 |
Genomic view of the DCXR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.