TFs regulating DCTN4 0 TFs

Transcription factors with Perturb-seq knockdown data for DCTN4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCTN4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DCTN4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCTN4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr5:150,458,741–150,459,365	300.0 kb	Distal (>10kb) Multiome	430
chr5:150,485,401–150,487,150	273.2 kb	Distal (>10kb) Multiome	761
chr5:150,577,977–150,578,481	180.7 kb	Distal (>10kb) Multiome	149
chr5:150,624,424–150,625,067	134.2 kb	Distal (>10kb) Multiome	250
chr5:150,656,143–150,657,405	102.3 kb	Distal (>10kb) Multiome	607
chr5:150,670,030–150,670,981	88.4 kb	Distal (>10kb) Multiome	69
chr5:150,671,571–150,672,919	86.6 kb	Distal (>10kb) Multiome	303
chr5:150,700,548–150,701,464	58.0 kb	Distal (>10kb) Multiome	858
chr5:150,758,281–150,759,438	174 bp	At TSS Multiome	902
chr5:150,778,240–150,779,492	20.0 kb	Distal (>10kb) Multiome	723
chr5:150,783,348–150,783,999	24.6 kb	Distal (>10kb) Multiome	435
chr5:150,801,105–150,801,901	42.5 kb	Distal (>10kb) Multiome	382
chr5:151,002,371–151,003,402	243.9 kb	Distal (>10kb) Multiome	132
chr5:151,020,249–151,021,200	261.5 kb	Distal (>10kb) Multiome	522

Genome Browser

Genomic view of the DCTN4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.