Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DCK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:70,703,846–70,706,278 | 288.9 kb | Distal (>10kb) Multiome | 934 | |
| chr4:70,836,603–70,837,949 | 156.4 kb | Distal (>10kb) Multiome | 136 | |
| chr4:70,838,760–70,840,084 | 153.7 kb | Distal (>10kb) Multiome | 828 | |
| chr4:70,901,672–70,903,467 | 91.3 kb | Distal (>10kb) Multiome | 915 | |
| chr4:70,992,414–70,994,232 | 33 bp | At TSS Multiome | 926 | |
| chr4:71,162,071–71,162,925 | 168.9 kb | Distal (>10kb) Multiome | 107 | |
| chr4:71,186,279–71,188,541 | 193.2 kb | Distal (>10kb) Multiome | 535 |
Genomic view of the DCK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.