This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]
Transcription factors with Perturb-seq knockdown data for DCAF4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCAF4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCAF4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:72,893,140–72,894,397 | 32.2 kb | Distal (>10kb) Multiome | 484 | |
| chr14:72,925,756–72,927,231 | 18 bp | At TSS Multiome | 799 | |
| chr14:73,026,575–73,027,593 | 100.8 kb | Distal (>10kb) Multiome | 727 | |
| chr14:73,058,025–73,059,316 | 132.1 kb | Distal (>10kb) Multiome | 949 | |
| chr14:73,136,098–73,137,113 | 210.1 kb | Distal (>10kb) Multiome | 737 |
Genomic view of the DCAF4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.