Predicted to be involved in protein ubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DCAF16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCAF16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCAF16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:17,511,108–17,512,753 | 298.6 kb | Distal (>10kb) Multiome | 724 | |
| chr4:17,576,452–17,578,383 | 233.5 kb | Distal (>10kb) Multiome | 874 | |
| chr4:17,613,634–17,615,353 | 196.1 kb | Distal (>10kb) Multiome | 740 | |
| chr4:17,636,469–17,637,277 | 173.8 kb | Distal (>10kb) Multiome | 322 | |
| chr4:17,780,838–17,782,239 | 29.1 kb | Distal (>10kb) Multiome | 374 | |
| chr4:17,808,589–17,809,005 | 1.8 kb | Proximal (<10kb) | 170 | |
| chr4:17,810,219–17,811,664 | 94 bp | At TSS Multiome | 935 | |
| chr4:17,817,167–17,817,310 | 6.4 kb | Proximal (<10kb) | 77 | |
| chr4:18,020,217–18,023,062 | 211.3 kb | Distal (>10kb) Multiome | 967 |
Genomic view of the DCAF16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.