Predicted to be involved in regulation of signal transduction. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DBNDD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DBNDD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DBNDD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:89,720,440–89,722,486 | 298.1 kb | Distal (>10kb) Multiome | 1048 | |
| chr16:89,816,022–89,817,100 | 202.7 kb | Distal (>10kb) Multiome | 995 | |
| chr16:89,827,667–89,829,190 | 191.0 kb | Distal (>10kb) Multiome | 784 | |
| chr16:89,872,618–89,874,723 | 145.3 kb | Distal (>10kb) Multiome | 1046 | |
| chr16:89,917,809–89,919,023 | 100.8 kb | Distal (>10kb) Multiome | 986 | |
| chr16:89,921,530–89,925,204 | 96.2 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:89,925,437–89,926,738 | 93.2 kb | Distal (>10kb) Multiome | 654 | |
| chr16:89,972,039–89,973,313 | 46.8 kb | Distal (>10kb) Multiome | 965 | |
| chr16:90,018,651–90,020,274 | 186 bp | At TSS Multiome | 634 | |
| chr16:90,046,432–90,047,827 | 27.4 kb | Distal (>10kb) Multiome | 700 | |
| chr16:90,077,247–90,078,026 | 58.0 kb | Distal (>10kb) Multiome | 412 | |
| chr16:90,081,997–90,082,775 | 62.7 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the DBNDD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.