The exact function of this gene is not known. It encodes a protein with a DALR anticodon binding domain similar to that of class Ia aminoacyl tRNA synthetases. This gene is located in a cluster of genes (with a complex sense-anti-sense genome architecture) on chromosome 3, and contains two micro RNA (miRNA) precursors (mir-425 and mir-191) in one of its introns. Preferential expression of this gene (the miRNAs and other genes in the cluster) in testis suggests a role of this gene in spermatogenesis (PMID:19906709). [provided by RefSeq, Feb 2013]
Transcription factors with Perturb-seq knockdown data for DALRD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DALRD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DALRD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:48,847,059–48,848,224 | 170.8 kb | Distal (>10kb) Multiome | 772 | |
| chr3:48,898,423–48,899,110 | 119.7 kb | Distal (>10kb) Multiome | 739 | |
| chr3:48,918,234–48,919,609 | 99.8 kb | Distal (>10kb) Multiome | 877 | |
| chr3:48,989,537–48,991,069 | 28.5 kb | Distal (>10kb) Multiome | 552 | |
| chr3:49,003,975–49,004,995 | 14.1 kb | Distal (>10kb) Multiome HiCAR | 209 | |
| chr3:49,006,738–49,008,496 | 10.7 kb | Distal (>10kb) Multiome HiCAR | 955 | |
| chr3:49,013,965–49,014,376 | 4.2 kb | Proximal (<10kb) | 210 | |
| chr3:49,017,789–49,018,870 | 100 bp | At TSS Multiome | 780 | |
| chr3:49,020,066–49,022,597 | 3.2 kb | Proximal (<10kb) Multiome | 1064 | |
| chr3:49,028,856–49,029,800 | 10.8 kb | Distal (>10kb) Multiome | 974 | |
| chr3:49,093,005–49,094,956 | 75.7 kb | Distal (>10kb) Multiome | 944 | |
| chr3:49,104,279–49,105,309 | 86.2 kb | Distal (>10kb) Multiome | 712 | |
| chr3:49,120,575–49,121,282 | 102.3 kb | Distal (>10kb) Multiome | 765 | |
| chr3:49,132,603–49,133,965 | 115.1 kb | Distal (>10kb) Multiome | 652 | |
| chr3:49,166,057–49,166,586 | 147.8 kb | Distal (>10kb) Multiome | 622 | |
| chr3:49,170,896–49,171,950 | 152.8 kb | Distal (>10kb) Multiome | 781 | |
| chr3:49,276,912–49,277,398 | 258.5 kb | Distal (>10kb) Multiome | 291 |
Genomic view of the DALRD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.