DAB2IP

DAB2IP

DAB2 interacting protein | AF9Q34, AIP1, DIP1/2, KIAA1743

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]

Member of: DE-3

Biological processes 141 terms

14-3-3 protein binding (GO:0071889)AIP1-IRE1 complex (GO:1990597)AIP1-IRE1 complex (GO:1990597)GTPase activator activity (GO:0005096)GTPase activator activity (GO:0005096)SH3 domain binding (GO:0017124)Toll-like receptor 4 binding (GO:0035662)axon (GO:0030424)axon (GO:0030424)cadherin binding (GO:0045296)cell motility involved in cerebral cortex radial glia guided migration (GO:0021814)cell motility involved in cerebral cortex radial glia guided migration (GO:0021814)cellular response to epidermal growth factor stimulus (GO:0071364)cellular response to interleukin-1 (GO:0071347)cellular response to interleukin-1 (GO:0071347)cellular response to lipopolysaccharide (GO:0071222)cellular response to lipopolysaccharide (GO:0071222)cellular response to tumor necrosis factor (GO:0071356)cellular response to tumor necrosis factor (GO:0071356)cellular response to unfolded protein (GO:0034620)cellular response to vascular endothelial growth factor stimulus (GO:0035924)cellular response to vascular endothelial growth factor stimulus (GO:0035924)cellular response to vascular endothelial growth factor stimulus (GO:0035924)cerebellar mossy fiber (GO:0044300)cerebellar mossy fiber (GO:0044300)climbing fiber (GO:0044301)climbing fiber (GO:0044301)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)death receptor binding (GO:0005123)dendrite (GO:0030425)endocytic vesicle (GO:0030139)endothelial cell apoptotic process (GO:0072577)extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)identical protein binding (GO:0042802)intracellular signal transduction (GO:0035556)intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)kinase binding (GO:0019900)layer formation in cerebral cortex (GO:0021819)layer formation in cerebral cortex (GO:0021819)lipid droplet formation (GO:0140042)membrane (GO:0016020)membrane (GO:0016020)mitogen-activated protein kinase kinase binding (GO:0031434)mitogen-activated protein kinase kinase kinase binding (GO:0031435)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of ERK1 and ERK2 cascade (GO:0070373)negative regulation of G0 to G1 transition (GO:0070317)negative regulation of GTPase activity (GO:0034260)negative regulation of MAPK cascade (GO:0043409)negative regulation of Ras protein signal transduction (GO:0046580)negative regulation of angiogenesis (GO:0016525)negative regulation of angiogenesis (GO:0016525)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of cell population proliferation (GO:0008285)negative regulation of endothelial cell migration (GO:0010596)negative regulation of endothelial cell migration (GO:0010596)negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)negative regulation of epithelial cell migration (GO:0010633)negative regulation of epithelial cell migration (GO:0010633)negative regulation of epithelial cell proliferation (GO:0050680)negative regulation of epithelial to mesenchymal transition (GO:0010719)negative regulation of epithelial to mesenchymal transition (GO:0010719)negative regulation of fibroblast proliferation (GO:0048147)negative regulation of fibroblast proliferation (GO:0048147)negative regulation of non-canonical NF-kappaB signal transduction (GO:1901223)negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051898)negative regulation of protein catabolic process (GO:0042177)negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)negative regulation of vascular endothelial growth factor signaling pathway (GO:1900747)negative regulation of vascular endothelial growth factor signaling pathway (GO:1900747)neuron projection morphogenesis (GO:0048812)neuron projection morphogenesis (GO:0048812)neuronal cell body (GO:0043025)neuronal cell body (GO:0043025)neuronal cell body membrane (GO:0032809)neuronal cell body membrane (GO:0032809)parallel fiber (GO:1990032)parallel fiber (GO:1990032)phosphatidylinositol 3-kinase binding (GO:0043548)phosphatidylinositol 3-kinase regulatory subunit binding (GO:0036312)phosphatidylinositol-3-phosphate binding (GO:0032266)phosphatidylinositol-4-phosphate binding (GO:0070273)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of GTPase activity (GO:0043547)positive regulation of IRE1-mediated unfolded protein response (GO:1903896)positive regulation of JNK cascade (GO:0046330)positive regulation of JNK cascade (GO:0046330)positive regulation of MAPK cascade (GO:0043410)positive regulation of apoptotic process (GO:0043065)positive regulation of apoptotic process (GO:0043065)positive regulation of apoptotic signaling pathway (GO:2001235)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of dendrite development (GO:1900006)positive regulation of dendrite development (GO:1900006)positive regulation of neuron migration (GO:2001224)positive regulation of neuron migration (GO:2001224)positive regulation of neuron projection development (GO:0010976)positive regulation of neuron projection development (GO:0010976)positive regulation of proteasomal protein catabolic process (GO:1901800)positive regulation of protein catabolic process (GO:0045732)positive regulation of protein catabolic process (GO:0045732)positive regulation of protein-containing complex assembly (GO:0031334)positive regulation of synapse maturation (GO:0090129)positive regulation of synapse maturation (GO:0090129)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein kinase binding (GO:0019901)protein kinase binding (GO:0019901)protein kinase binding (GO:0019901)protein phosphatase 2A binding (GO:0051721)protein serine/threonine kinase activator activity (GO:0043539)protein-containing complex binding (GO:0044877)regulation of GTPase activity (GO:0043087)regulation of canonical NF-kappaB signal transduction (GO:0043122)regulation of canonical NF-kappaB signal transduction (GO:0043122)regulation of cell cycle (GO:0051726)regulation of intracellular signal transduction (GO:1902531)regulation of p38MAPK cascade (GO:1900744)regulation of p38MAPK cascade (GO:1900744)regulation of protein-containing complex assembly (GO:0043254)regulation of protein-containing complex assembly (GO:0043254)signaling adaptor activity (GO:0035591)tube formation (GO:0035148)tube formation (GO:0035148)tumor necrosis factor-mediated signaling pathway (GO:0033209)vascular endothelial growth factor receptor 2 binding (GO:0043184)vascular endothelial growth factor receptor-2 signaling pathway (GO:0036324)vascular endothelial growth factor receptor-2 signaling pathway (GO:0036324)

Expression (TPM)

TFs regulating DAB2IP 0 TFs

Transcription factors with Perturb-seq knockdown data for DAB2IP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DAB2IP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DAB2IP

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DAB2IP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr9:121,299,542–121,300,058	298.5 kb	Distal (>10kb) Multiome	428
	chr9:121,369,661–121,370,788	227.9 kb	Distal (>10kb) Multiome	849
	chr9:121,499,468–121,500,318	98.3 kb	Distal (>10kb) Multiome	361
	chr9:121,545,736–121,546,521	52.1 kb	Distal (>10kb) Multiome	559
	chr9:121,550,534–121,551,203	47.5 kb	Distal (>10kb) Multiome	479
	chr9:121,573,659–121,574,394	24.3 kb	Distal (>10kb) Multiome	41
	chr9:121,597,811–121,598,880	35 bp	At TSS Multiome	345
	chr9:121,598,949–121,600,205	1.2 kb	Proximal (<10kb) Multiome	448
	chr9:121,650,102–121,650,775	52.1 kb	Distal (>10kb) Multiome	435
	chr9:121,651,183–121,652,085	53.3 kb	Distal (>10kb) Multiome	493
	chr9:121,652,423–121,652,797	790 bp	At TSS	141
	chr9:121,698,540–121,700,112	100.8 kb	Distal (>10kb) Multiome	344
	chr9:121,735,894–121,737,240	138.3 kb	Distal (>10kb) Multiome	407
	chr9:121,835,667–121,836,406	237.8 kb	Distal (>10kb) Multiome	85

Genome Browser

Genomic view of the DAB2IP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.