The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Transcription factors with Perturb-seq knockdown data for CYTH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYTH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYTH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:48,169,480–48,171,282 | 298.8 kb | Distal (>10kb) Multiome | 950 | |
| chr19:48,203,709–48,204,551 | 265.3 kb | Distal (>10kb) Multiome | 741 | |
| chr19:48,271,198–48,272,050 | 197.8 kb | Distal (>10kb) Multiome | 562 | |
| chr19:48,290,181–48,291,716 | 178.5 kb | Distal (>10kb) Multiome | 666 | |
| chr19:48,320,062–48,322,328 | 147.8 kb | Distal (>10kb) Multiome | 826 | |
| chr19:48,330,094–48,330,787 | 139.0 kb | Distal (>10kb) Multiome | 460 | |
| chr19:48,332,701–48,333,506 | 136.4 kb | Distal (>10kb) Multiome | 615 | |
| chr19:48,333,584–48,334,372 | 135.2 kb | Distal (>10kb) Multiome | 554 | |
| chr19:48,363,062–48,364,710 | 105.1 kb | Distal (>10kb) Multiome | 940 | |
| chr19:48,390,663–48,391,935 | 77.7 kb | Distal (>10kb) Multiome | 816 | |
| chr19:48,397,916–48,399,301 | 70.5 kb | Distal (>10kb) Multiome | 619 | |
| chr19:48,399,411–48,400,900 | 68.7 kb | Distal (>10kb) Multiome | 548 | |
| chr19:48,414,121–48,416,085 | 53.8 kb | Distal (>10kb) Multiome | 298 | |
| chr19:48,445,379–48,446,456 | 23.4 kb | Distal (>10kb) Multiome | 845 | |
| chr19:48,462,365–48,462,576 | 6.7 kb | Proximal (<10kb) | 207 | |
| chr19:48,468,758–48,470,027 | 169 bp | At TSS Multiome | 860 | |
| chr19:48,490,661–48,494,449 | 22.0 kb | Distal (>10kb) Multiome | 633 | |
| chr19:48,500,898–48,503,050 | 32.8 kb | Distal (>10kb) Multiome | 656 | |
| chr19:48,510,624–48,511,212 | 41.5 kb | Distal (>10kb) Multiome | 268 | |
| chr19:48,513,480–48,514,294 | 44.6 kb | Distal (>10kb) Multiome | 585 | |
| chr19:48,614,318–48,615,255 | 145.6 kb | Distal (>10kb) Multiome | 524 | |
| chr19:48,618,726–48,619,869 | 150.1 kb | Distal (>10kb) Multiome | 1012 | |
| chr19:48,623,839–48,624,688 | 154.9 kb | Distal (>10kb) Multiome | 529 | |
| chr19:48,629,369–48,631,306 | 160.7 kb | Distal (>10kb) Multiome | 402 | |
| chr19:48,634,242–48,636,244 | 166.4 kb | Distal (>10kb) Multiome | 868 | |
| chr19:48,636,802–48,639,603 | 169.1 kb | Distal (>10kb) Multiome | 956 | |
| chr19:48,645,454–48,647,163 | 177.3 kb | Distal (>10kb) Multiome | 750 | |
| chr19:48,675,421–48,675,873 | 206.3 kb | Distal (>10kb) Multiome | 415 | |
| chr19:48,695,830–48,697,033 | 226.8 kb | Distal (>10kb) Multiome | 253 | |
| chr19:48,713,646–48,714,846 | 245.0 kb | Distal (>10kb) Multiome | 719 | |
| chr19:48,716,551–48,717,038 | 247.6 kb | Distal (>10kb) Multiome | 241 | |
| chr19:48,720,420–48,721,301 | 251.6 kb | Distal (>10kb) Multiome | 689 | |
| chr19:48,735,001–48,735,602 | 265.9 kb | Distal (>10kb) Multiome | 161 | |
| chr19:48,738,441–48,739,812 | 269.6 kb | Distal (>10kb) Multiome | 743 | |
| chr19:48,741,194–48,741,939 | 272.3 kb | Distal (>10kb) Multiome | 350 | |
| chr19:48,746,830–48,747,395 | 277.8 kb | Distal (>10kb) Multiome | 402 | |
| chr19:48,752,314–48,753,547 | 283.6 kb | Distal (>10kb) Multiome | 545 |
Genomic view of the CYTH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.