CYP2C8
cytochrome P450 family 2 subfamily C member 8 | CPC8

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Biological processes 40 terms
arachidonate epoxygenase activity (GO:0008392)arachidonate metabolic process (GO:0019369)caffeine oxidase activity (GO:0034875)cytoplasm (GO:0005737)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)epoxygenase P450 pathway (GO:0019373)epoxygenase P450 pathway (GO:0019373)epoxygenase P450 pathway (GO:0019373)estrogen 16-alpha-hydroxylase activity (GO:0101020)estrogen 16-alpha-hydroxylase activity (GO:0101020)estrogen metabolic process (GO:0008210)heme binding (GO:0020037)heme binding (GO:0020037)icosanoid biosynthetic process (GO:0046456)intracellular membrane-bounded organelle (GO:0043231)iron ion binding (GO:0005506)lipid hydroxylation (GO:0002933)long-chain fatty acid biosynthetic process (GO:0042759)monocarboxylic acid metabolic process (GO:0032787)monooxygenase activity (GO:0004497)monooxygenase activity (GO:0004497)monooxygenase activity (GO:0004497)omega-hydroxylase P450 pathway (GO:0097267)organic acid metabolic process (GO:0006082)oxidative demethylation (GO:0070989)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (GO:0016712)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (GO:0016712)protein binding (GO:0005515)retinoic acid 4-hydroxylase activity (GO:0008401)retinoic acid metabolic process (GO:0042573)retinol metabolic process (GO:0042572)steroid metabolic process (GO:0008202)terpenoid metabolic process (GO:0006721)xenobiotic catabolic process (GO:0042178)xenobiotic catabolic process (GO:0042178)xenobiotic metabolic process (GO:0006805)xenobiotic metabolic process (GO:0006805)xenobiotic metabolic process (GO:0006805)
Expression (TPM)
Huangfu Lab · Publications · Resources · Contact