This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Transcription factors with Perturb-seq knockdown data for CYP26B1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYP26B1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYP26B1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:72,137,371–72,137,974 | 5.1 kb | Proximal (<10kb) | 324 | |
| chr2:72,142,925–72,143,870 | at TSS | At TSS | 202 | |
| chr2:72,144,434–72,145,640 | 1.4 kb | Proximal (<10kb) | 473 | |
| chr2:72,147,066–72,147,950 | 4.0 kb | Proximal (<10kb) | 206 | |
| chr2:72,148,947–72,149,709 | 5.9 kb | Proximal (<10kb) | 267 | |
| chr2:72,149,850–72,150,987 | 6.8 kb | Proximal (<10kb) | 364 |
Genomic view of the CYP26B1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.