Involved in innate immune response and respiratory burst after phagocytosis. Located in endoplasmic reticulum. Implicated in autosomal recessive chronic granulomatous disease 5. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CYBC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYBC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYBC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:82,212,405–82,213,592 | 237.8 kb | Distal (>10kb) Multiome | 911 | |
| chr17:82,228,266–82,232,536 | 221.8 kb | Distal (>10kb) Multiome | 1048 | |
| chr17:82,272,608–82,274,062 | 177.0 kb | Distal (>10kb) Multiome | 943 | |
| chr17:82,278,488–82,279,226 | 171.8 kb | Distal (>10kb) Multiome | 229 | |
| chr17:82,292,400–82,293,256 | 157.8 kb | Distal (>10kb) Multiome | 944 | |
| chr17:82,414,581–82,415,044 | 35.9 kb | Distal (>10kb) Multiome | 799 | |
| chr17:82,417,993–82,419,018 | 32.2 kb | Distal (>10kb) Multiome | 844 | |
| chr17:82,450,369–82,451,002 | 71 bp | At TSS Multiome | 837 | |
| chr17:82,458,067–82,459,318 | 7.8 kb | Proximal (<10kb) Multiome | 1054 | |
| chr17:82,494,122–82,495,128 | 44.0 kb | Distal (>10kb) Multiome | 1010 | |
| chr17:82,496,968–82,497,781 | 46.6 kb | Distal (>10kb) Multiome | 613 | |
| chr17:82,519,154–82,520,226 | 68.9 kb | Distal (>10kb) Multiome | 869 | |
| chr17:82,647,682–82,648,684 | 197.9 kb | Distal (>10kb) Multiome | 874 | |
| chr17:82,697,983–82,699,271 | 248.1 kb | Distal (>10kb) Multiome | 623 | |
| chr17:82,715,983–82,717,178 | 265.8 kb | Distal (>10kb) Multiome | 744 | |
| chr17:82,735,174–82,736,034 | 284.8 kb | Distal (>10kb) Multiome | 649 |
Genomic view of the CYBC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.