Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CYBA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYBA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYBA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:88,382,901–88,383,561 | 267.8 kb | Distal (>10kb) Multiome | 166 | |
| chr16:88,452,301–88,456,281 | 195.4 kb | Distal (>10kb) Multiome | 1032 | |
| chr16:88,468,411–88,469,072 | 182.3 kb | Distal (>10kb) Multiome | 251 | |
| chr16:88,533,022–88,535,493 | 117.0 kb | Distal (>10kb) Multiome | 458 | |
| chr16:88,569,589–88,571,104 | 80.7 kb | Distal (>10kb) Multiome | 904 | |
| chr16:88,634,178–88,635,155 | 16.4 kb | Distal (>10kb) Multiome | 384 | |
| chr16:88,650,385–88,651,684 | 70 bp | At TSS Multiome | 890 | |
| chr16:88,662,399–88,664,138 | 12.2 kb | Distal (>10kb) Multiome | 943 | |
| chr16:88,686,082–88,687,017 | 35.5 kb | Distal (>10kb) Multiome | 675 | |
| chr16:88,705,859–88,706,820 | 55.4 kb | Distal (>10kb) Multiome | 838 | |
| chr16:88,737,237–88,737,815 | 86.5 kb | Distal (>10kb) Multiome | 619 | |
| chr16:88,769,688–88,770,137 | 118.7 kb | Distal (>10kb) Multiome | 282 | |
| chr16:88,770,700–88,771,325 | 120.0 kb | Distal (>10kb) Multiome | 668 | |
| chr16:88,784,542–88,785,880 | 134.3 kb | Distal (>10kb) Multiome | 811 | |
| chr16:88,802,766–88,805,068 | 152.6 kb | Distal (>10kb) Multiome | 881 | |
| chr16:88,810,968–88,812,892 | 161.0 kb | Distal (>10kb) Multiome | 1059 | |
| chr16:88,856,080–88,858,003 | 205.9 kb | Distal (>10kb) Multiome | 885 | |
| chr16:88,940,964–88,942,110 | 290.9 kb | Distal (>10kb) Multiome | 323 |
Genomic view of the CYBA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.