Predicted to enable heme binding activity. Predicted to be involved in nervous system development. Predicted to act upstream of or within positive regulation of neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in endomembrane system and membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CYB5D2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYB5D2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYB5D2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:3,845,518–3,846,549 | 296.9 kb | Distal (>10kb) Multiome | 917 | |
| chr17:3,891,925–3,893,745 | 249.9 kb | Distal (>10kb) Multiome | 716 | |
| chr17:3,944,497–3,945,384 | 198.3 kb | Distal (>10kb) Multiome | 277 | |
| chr17:3,964,969–3,965,418 | 177.9 kb | Distal (>10kb) Multiome | 333 | |
| chr17:4,003,950–4,004,421 | 139.2 kb | Distal (>10kb) Multiome | 404 | |
| chr17:4,004,672–4,005,109 | 138.3 kb | Distal (>10kb) Multiome | 632 | |
| chr17:4,142,469–4,144,218 | 661 bp | At TSS Multiome | 1007 | |
| chr17:4,263,266–4,264,359 | 120.8 kb | Distal (>10kb) Multiome | 729 | |
| chr17:4,365,147–4,367,069 | 222.2 kb | Distal (>10kb) Multiome | 911 |
Genomic view of the CYB5D2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.