This gene encodes a factor that is part of the multi-protein C complex involved in pre-mRNA splicing. Alternatively spliced transcripts have been described for this gene. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for CWC25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CWC25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CWC25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:38,558,106–38,558,652 | 267.0 kb | Distal (>10kb) Multiome | 631 | |
| chr17:38,559,205–38,559,900 | 265.7 kb | Distal (>10kb) Multiome | 598 | |
| chr17:38,572,553–38,573,232 | 252.3 kb | Distal (>10kb) Multiome | 231 | |
| chr17:38,604,448–38,605,250 | 220.4 kb | Distal (>10kb) Multiome | 375 | |
| chr17:38,605,359–38,606,888 | 218.8 kb | Distal (>10kb) Multiome | 781 | |
| chr17:38,609,172–38,610,061 | 215.7 kb | Distal (>10kb) Multiome | 229 | |
| chr17:38,673,658–38,675,315 | 150.3 kb | Distal (>10kb) Multiome | 847 | |
| chr17:38,701,857–38,703,072 | 122.9 kb | Distal (>10kb) Multiome | 907 | |
| chr17:38,703,568–38,704,668 | 121.3 kb | Distal (>10kb) Multiome | 955 | |
| chr17:38,704,725–38,707,220 | 119.9 kb | Distal (>10kb) Multiome | 784 | |
| chr17:38,718,492–38,719,127 | 106.6 kb | Distal (>10kb) Multiome | 268 | |
| chr17:38,719,228–38,720,635 | 105.1 kb | Distal (>10kb) Multiome | 290 | |
| chr17:38,729,824–38,730,713 | 95.1 kb | Distal (>10kb) Multiome | 794 | |
| chr17:38,747,498–38,750,334 | 75.5 kb | Distal (>10kb) Multiome | 914 | |
| chr17:38,751,747–38,753,201 | 73.6 kb | Distal (>10kb) Multiome | 986 | |
| chr17:38,789,155–38,789,604 | 35.9 kb | Distal (>10kb) Multiome | 144 | |
| chr17:38,798,912–38,800,293 | 25.4 kb | Distal (>10kb) Multiome | 966 | |
| chr17:38,824,673–38,825,720 | 1 bp | At TSS Multiome | 978 | |
| chr17:38,853,382–38,854,144 | 28.4 kb | Distal (>10kb) Multiome | 1047 | |
| chr17:38,867,391–38,868,381 | 42.4 kb | Distal (>10kb) Multiome | 640 | |
| chr17:38,869,253–38,871,194 | 44.5 kb | Distal (>10kb) Multiome | 1074 | |
| chr17:38,900,769–38,901,637 | 76.0 kb | Distal (>10kb) Multiome | 370 | |
| chr17:38,967,321–38,967,861 | 142.2 kb | Distal (>10kb) Multiome | 219 | |
| chr17:39,011,896–39,012,455 | 186.8 kb | Distal (>10kb) Multiome | 81 | |
| chr17:39,056,695–39,057,296 | 231.7 kb | Distal (>10kb) Multiome | 468 |
Genomic view of the CWC25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.