The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for CTNNBL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTNNBL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTNNBL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:37,396,207–37,397,008 | 297.5 kb | Distal (>10kb) Multiome | 227 | |
| chr20:37,520,318–37,521,734 | 172.8 kb | Distal (>10kb) Multiome | 237 | |
| chr20:37,527,439–37,528,617 | 166.1 kb | Distal (>10kb) Multiome | 899 | |
| chr20:37,564,323–37,564,876 | 129.5 kb | Distal (>10kb) Multiome | 440 | |
| chr20:37,693,635–37,694,526 | 87 bp | At TSS Multiome | 809 | |
| chr20:37,845,138–37,846,093 | 151.5 kb | Distal (>10kb) Multiome | 127 | |
| chr20:37,914,632–37,915,455 | 221.0 kb | Distal (>10kb) Multiome | 382 |
Genomic view of the CTNNBL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.