CTNNBIP1
catenin beta interacting protein 1 | ICAT, MGC15093

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Member of: DE-1
Biological processes 33 terms
armadillo repeat domain binding (GO:0070016)beta-catenin binding (GO:0008013)beta-catenin binding (GO:0008013)beta-catenin binding (GO:0008013)beta-catenin destruction complex (GO:0030877)beta-catenin destruction complex (GO:0030877)canonical Wnt signaling pathway (GO:0060070)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)negative regulation of Wnt signaling pathway (GO:0030178)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of cell population proliferation (GO:0008285)negative regulation of mesenchymal cell proliferation (GO:0072201)negative regulation of protein-containing complex assembly (GO:0031333)negative regulation of smooth muscle cell proliferation (GO:0048662)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription initiation by RNA polymerase II (GO:0060633)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of monocyte differentiation (GO:0045657)positive regulation of osteoblast differentiation (GO:0045669)protein binding (GO:0005515)protein-containing complex (GO:0032991)regulation of vascular permeability involved in acute inflammatory response (GO:0002528)transcription coactivator binding (GO:0001223)transcription regulator inhibitor activity (GO:0140416)
Expression (TPM)
CTNNBIP1 — as a Regulated Gene

TFs regulating CTNNBIP1 0 TFs

Transcription factors with Perturb-seq knockdown data for CTNNBIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTNNBIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CTNNBIP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTNNBIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:9,627,002–9,627,511 283.2 kb Distal (>10kb) Multiome 773
chr1:9,651,631–9,652,549 258.3 kb Distal (>10kb) Multiome 373
chr1:9,687,158–9,688,089 222.7 kb Distal (>10kb) Multiome 575
chr1:9,688,950–9,690,301 220.8 kb Distal (>10kb) Multiome 585
chr1:9,823,213–9,824,739 86.3 kb Distal (>10kb) Multiome 652
chr1:9,874,956–9,875,558 35.2 kb Distal (>10kb) Multiome 397
chr1:9,909,556–9,911,240 135 bp At TSS Multiome 791
chr1:9,942,849–9,943,619 33.0 kb Distal (>10kb) Multiome 1015
chr1:10,032,377–10,033,814 122.5 kb Distal (>10kb) Multiome 891
chr1:10,209,800–10,211,585 300.1 kb Distal (>10kb) Multiome 934

Genome Browser

Genomic view of the CTNNBIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:9,617,002 – 10,221,585
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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