Predicted to enable actin filament binding activity and cadherin binding activity. Acts upstream of or within Rho protein signal transduction. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CTNNAL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTNNAL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTNNAL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:108,933,334–108,934,940 | 79.3 kb | Distal (>10kb) Multiome | 940 | |
| chr9:109,012,369–109,014,144 | 72 bp | At TSS Multiome | 780 | |
| chr9:109,022,941–109,023,283 | 9.4 kb | Proximal (<10kb) | 165 | |
| chr9:109,118,835–109,120,627 | 106.5 kb | Distal (>10kb) Multiome | 832 | |
| chr9:109,166,465–109,167,517 | 153.6 kb | Distal (>10kb) Multiome | 131 |
Genomic view of the CTNNAL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.