Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Located in extracellular exosome. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CTDSPL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTDSPL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTDSPL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:37,693,741–37,694,487 | 167.8 kb | Distal (>10kb) Multiome | 152 | |
| chr3:37,855,450–37,855,671 | 6.2 kb | Proximal (<10kb) | 268 | |
| chr3:37,859,865–37,862,804 | 1.3 kb | Proximal (<10kb) Multiome | 1005 | |
| chr3:37,986,618–37,987,603 | 125.2 kb | Distal (>10kb) Multiome HiCAR | 525 | |
| chr3:37,993,686–37,994,594 | 132.4 kb | Distal (>10kb) Multiome HiCAR | 519 | |
| chr3:37,998,336–37,999,630 | 137.2 kb | Distal (>10kb) Multiome HiCAR | 510 | |
| chr3:38,003,084–38,004,028 | 141.6 kb | Distal (>10kb) Multiome | 352 | |
| chr3:38,023,878–38,025,927 | 163.0 kb | Distal (>10kb) Multiome | 762 | |
| chr3:38,028,710–38,030,184 | 167.8 kb | Distal (>10kb) Multiome | 378 | |
| chr3:38,039,093–38,039,944 | 177.5 kb | Distal (>10kb) Multiome | 357 | |
| chr3:38,136,419–38,139,307 | 276.9 kb | Distal (>10kb) Multiome | 989 |
Genomic view of the CTDSPL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.