This gene encodes the alpha', or alpha 2, catalytic subunit of the protein kinase enzyme, casein kinase 2 (CK2). Casein kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. This heterotetrameric kinase includes two catalytic subunits, either alpha or alpha', and two regulatory beta subunits. The closely related gene paralog encoding the alpha, or alpha 1 subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An intronic variant in this gene (alpha 2) may be associated with leukocyte telomere length in a South Asian population. A related transcribed pseudogene is found on chromosome 11. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for CSNK2A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSNK2A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSNK2A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:57,984,418–57,986,121 | 213.1 kb | Distal (>10kb) Multiome | 447 | |
| chr16:57,999,954–58,001,881 | 196.9 kb | Distal (>10kb) Multiome | 920 | |
| chr16:58,024,574–58,028,306 | 172.5 kb | Distal (>10kb) Multiome | 1046 | |
| chr16:58,032,341–58,033,244 | 165.3 kb | Distal (>10kb) Multiome | 283 | |
| chr16:58,128,725–58,130,027 | 68.6 kb | Distal (>10kb) Multiome | 1095 | |
| chr16:58,197,509–58,198,705 | 86 bp | At TSS Multiome | 490 | |
| chr16:58,236,247–58,236,852 | 38.5 kb | Distal (>10kb) Multiome | 355 | |
| chr16:58,249,584–58,250,557 | 51.9 kb | Distal (>10kb) Multiome | 641 | |
| chr16:58,392,269–58,393,124 | 194.5 kb | Distal (>10kb) Multiome | 993 | |
| chr16:58,463,143–58,465,363 | 265.6 kb | Distal (>10kb) Multiome | 307 | |
| chr16:58,487,547–58,488,283 | 289.7 kb | Distal (>10kb) Multiome | 523 |
Genomic view of the CSNK2A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.