This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is involved in elongation during chondroitin sulfate synthesis. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome X. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for CSGALNACT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSGALNACT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSGALNACT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:42,866,108–42,867,222 | 271.6 kb | Distal (>10kb) Multiome HiCAR | 204 | |
| chr10:42,932,398–42,934,239 | 205.5 kb | Distal (>10kb) Multiome | 252 | |
| chr10:42,951,596–42,953,009 | 186.1 kb | Distal (>10kb) Multiome | 263 | |
| chr10:43,026,131–43,027,199 | 111.6 kb | Distal (>10kb) Multiome | 308 | |
| chr10:43,076,256–43,078,068 | 61.4 kb | Distal (>10kb) Multiome | 337 | |
| chr10:43,104,555–43,106,082 | 32.9 kb | Distal (>10kb) Multiome | 582 | |
| chr10:43,137,532–43,139,055 | 28 bp | At TSS Multiome | 754 | |
| chr10:43,202,016–43,204,485 | 64.4 kb | Distal (>10kb) Multiome | 505 | |
| chr10:43,204,643–43,205,459 | 66.7 kb | Distal (>10kb) Multiome | 272 | |
| chr10:43,228,465–43,230,305 | 91.3 kb | Distal (>10kb) Multiome | 290 | |
| chr10:43,265,915–43,267,309 | 128.4 kb | Distal (>10kb) Multiome | 244 | |
| chr10:43,322,425–43,323,518 | 184.5 kb | Distal (>10kb) Multiome | 215 | |
| chr10:43,361,820–43,362,935 | 224.0 kb | Distal (>10kb) Multiome | 416 | |
| chr10:43,395,694–43,397,607 | 257.7 kb | Distal (>10kb) Multiome | 1120 | |
| chr10:43,407,131–43,410,086 | 270.7 kb | Distal (>10kb) Multiome | 1109 | |
| chr10:43,420,185–43,421,230 | 282.2 kb | Distal (>10kb) Multiome | 1071 | |
| chr10:43,436,316–43,437,609 | 298.5 kb | Distal (>10kb) Multiome | 970 |
Genomic view of the CSGALNACT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.