This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for CRTAC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRTAC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRTAC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:97,736,595–97,737,824 | 293.5 kb | Distal (>10kb) Multiome | 1009 | |
| chr10:97,771,123–97,772,389 | 258.9 kb | Distal (>10kb) Multiome | 356 | |
| chr10:97,849,566–97,850,474 | 180.5 kb | Distal (>10kb) Multiome | 400 | |
| chr10:98,028,093–98,028,502 | 2.1 kb | Proximal (<10kb) | 131 | |
| chr10:98,029,703–98,031,553 | 139 bp | At TSS Multiome | 325 | |
| chr10:98,038,336–98,038,651 | 7.7 kb | Proximal (<10kb) | 153 | |
| chr10:98,134,300–98,135,354 | 104.1 kb | Distal (>10kb) Multiome | 772 | |
| chr10:98,309,066–98,309,892 | 279.1 kb | Distal (>10kb) Multiome | 380 |
Genomic view of the CRTAC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.