Predicted to enable glycosaminoglycan binding activity. Involved in face morphogenesis. Located in transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CRISPLD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRISPLD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRISPLD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:84,617,446–84,619,117 | 223.8 kb | Distal (>10kb) Multiome | 844 | |
| chr16:84,648,019–84,649,061 | 193.5 kb | Distal (>10kb) Multiome | 797 | |
| chr16:84,699,238–84,700,817 | 142.1 kb | Distal (>10kb) Multiome | 876 | |
| chr16:84,819,303–84,820,380 | 22.2 kb | Distal (>10kb) Multiome | 496 | |
| chr16:84,841,652–84,842,331 | 30 bp | At TSS Multiome | 196 | |
| chr16:85,011,017–85,012,043 | 169.5 kb | Distal (>10kb) Multiome | 927 | |
| chr16:85,027,317–85,028,400 | 185.7 kb | Distal (>10kb) Multiome | 815 |
Genomic view of the CRISPLD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.