Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for CRIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:105,248,175–105,249,386 | 238.6 kb | Distal (>10kb) Multiome | 403 | |
| chr14:105,299,994–105,301,984 | 185.9 kb | Distal (>10kb) Multiome | 829 | |
| chr14:105,313,768–105,315,755 | 172.6 kb | Distal (>10kb) Multiome | 584 | |
| chr14:105,352,048–105,352,515 | 134.8 kb | Distal (>10kb) Multiome | 344 | |
| chr14:105,398,137–105,398,986 | 88.7 kb | Distal (>10kb) Multiome | 870 | |
| chr14:105,411,005–105,411,818 | 75.8 kb | Distal (>10kb) Multiome | 384 | |
| chr14:105,414,940–105,415,397 | 72.1 kb | Distal (>10kb) Multiome | 447 | |
| chr14:105,419,281–105,420,109 | 67.3 kb | Distal (>10kb) Multiome | 570 | |
| chr14:105,448,471–105,448,924 | 38.4 kb | Distal (>10kb) Multiome | 304 | |
| chr14:105,473,498–105,475,498 | 12.9 kb | Distal (>10kb) Multiome | 581 | |
| chr14:105,480,543–105,482,375 | 6.2 kb | Proximal (<10kb) Multiome | 784 | |
| chr14:105,485,648–105,486,379 | 1.3 kb | Proximal (<10kb) Multiome | 424 | |
| chr14:105,486,576–105,487,923 | 55 bp | At TSS Multiome | 369 | |
| chr14:105,489,310–105,492,133 | 3.8 kb | Proximal (<10kb) Multiome | 1014 | |
| chr14:105,526,110–105,527,233 | 39.4 kb | Distal (>10kb) Multiome | 270 | |
| chr14:105,528,085–105,528,965 | 41.3 kb | Distal (>10kb) Multiome | 568 |
Genomic view of the CRIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.