Transcription factors with Perturb-seq knockdown data for CRIM1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRIM1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRIM1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:36,270,781–36,271,600 | 84.4 kb | Distal (>10kb) Multiome | 174 | |
| chr2:36,352,109–36,352,318 | 3.2 kb | Proximal (<10kb) | 82 | |
| chr2:36,352,585–36,352,987 | 2.5 kb | Proximal (<10kb) | 64 | |
| chr2:36,354,870–36,358,367 | 217 bp | At TSS Multiome | 937 | |
| chr2:36,597,155–36,598,540 | 242.4 kb | Distal (>10kb) Multiome | 777 |
Genomic view of the CRIM1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.