This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for CREB3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CREB3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CREB3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:35,489,223–35,490,919 | 242.6 kb | Distal (>10kb) Multiome | 918 | |
| chr9:35,603,584–35,606,173 | 128.4 kb | Distal (>10kb) Multiome | 918 | |
| chr9:35,645,821–35,647,298 | 86.7 kb | Distal (>10kb) Multiome | 734 | |
| chr9:35,657,275–35,659,114 | 74.5 kb | Distal (>10kb) Multiome | 1156 | |
| chr9:35,664,903–35,665,580 | 67.3 kb | Distal (>10kb) Multiome | 814 | |
| chr9:35,675,371–35,676,451 | 56.7 kb | Distal (>10kb) Multiome | 223 | |
| chr9:35,689,224–35,691,525 | 41.4 kb | Distal (>10kb) Multiome | 541 | |
| chr9:35,729,814–35,729,984 | 2.6 kb | Proximal (<10kb) | 236 | |
| chr9:35,731,682–35,733,531 | 237 bp | At TSS Multiome | 920 | |
| chr9:35,736,174–35,736,592 | 3.6 kb | Proximal (<10kb) | 166 | |
| chr9:35,748,884–35,750,005 | 16.7 kb | Distal (>10kb) Multiome | 667 | |
| chr9:35,756,620–35,757,642 | 24.4 kb | Distal (>10kb) Multiome | 810 | |
| chr9:35,790,361–35,791,220 | 58.0 kb | Distal (>10kb) Multiome | 282 | |
| chr9:35,791,337–35,791,986 | 59.1 kb | Distal (>10kb) Multiome | 98 | |
| chr9:35,811,906–35,812,486 | 79.6 kb | Distal (>10kb) Multiome | 610 | |
| chr9:35,814,402–35,815,681 | 82.6 kb | Distal (>10kb) Multiome | 896 | |
| chr9:35,828,657–35,829,781 | 96.7 kb | Distal (>10kb) Multiome | 419 | |
| chr9:35,845,853–35,846,711 | 113.7 kb | Distal (>10kb) Multiome | 141 |
Genomic view of the CREB3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.