Enables GTPase activity and calcium ion binding activity. Involved in several processes, including activation of store-operated calcium channel activity; positive regulation of JNK cascade; and store-operated calcium entry. Located in several cellular components, including Golgi apparatus; Weibel-Palade body; and immunological synapse. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CRACR2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRACR2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRACR2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:3,491,725–3,492,673 | 260.9 kb | Distal (>10kb) Multiome | 517 | |
| chr12:3,705,291–3,706,096 | 47.5 kb | Distal (>10kb) Multiome HiCAR | 29 | |
| chr12:3,752,872–3,753,459 | 31 bp | At TSS Multiome | 419 | |
| chr12:3,872,846–3,873,625 | 120.1 kb | Distal (>10kb) Multiome | 538 | |
| chr12:4,024,691–4,026,063 | 272.5 kb | Distal (>10kb) Multiome | 356 | |
| chr12:4,030,924–4,031,732 | 278.1 kb | Distal (>10kb) Multiome | 478 |
Genomic view of the CRACR2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.