Acts upstream of or within regulation of complement activation and regulation of complement-dependent cytotoxicity. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CR1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CR1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CR1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:207,453,941–207,454,999 | 190.8 kb | Distal (>10kb) Multiome | 525 | |
| chr1:207,579,217–207,579,858 | 65.6 kb | Distal (>10kb) Multiome | 258 | |
| chr1:207,633,750–207,634,299 | 11.1 kb | Distal (>10kb) Multiome | 77 | |
| chr1:207,635,441–207,635,962 | 9.1 kb | Proximal (<10kb) | 200 | |
| chr1:207,644,651–207,646,070 | 86 bp | At TSS Multiome | 404 | |
| chr1:207,648,976–207,650,420 | 3.9 kb | Proximal (<10kb) | 256 | |
| chr1:207,751,438–207,753,038 | 106.9 kb | Distal (>10kb) Multiome | 886 | |
| chr1:207,868,258–207,869,634 | 224.0 kb | Distal (>10kb) Multiome | 605 |
Genomic view of the CR1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.