CORO2B

coronin 2B | ClipinC, KIAA0925

Enables talin binding activity and vinculin binding activity. Acts upstream of or within several processes, including negative regulation of cell-substrate adhesion; regulation of actin cytoskeleton organization; and regulation of establishment of protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 20 terms

actin binding (GO:0003779)actin cytoskeleton (GO:0015629)actin cytoskeleton organization (GO:0030036)actin filament (GO:0005884)actin filament binding (GO:0051015)actin filament organization (GO:0007015)cytoskeleton (GO:0005856)focal adhesion (GO:0005925)focal adhesion (GO:0005925)focal adhesion assembly (GO:0048041)membrane (GO:0016020)negative regulation of cell-substrate adhesion (GO:0010812)negative regulation of establishment of protein localization (GO:1904950)plasma membrane (GO:0005886)positive regulation of establishment of protein localization (GO:1904951)protein binding (GO:0005515)regulation of actin cytoskeleton organization (GO:0032956)regulation of cellular response to stress (GO:0080135)talin binding (GO:1990147)vinculin binding (GO:0017166)

Expression (TPM)

TFs regulating CORO2B 0 TFs

Transcription factors with Perturb-seq knockdown data for CORO2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CORO2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CORO2B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CORO2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr15:68,431,141–68,432,391	184.4 kb	Distal (>10kb) Multiome	295
chr15:68,559,409–68,560,165	56.7 kb	Distal (>10kb) Multiome	531
chr15:68,578,463–68,579,020	at TSS	At TSS	337
chr15:68,579,077–68,579,774	37.3 kb	Distal (>10kb) Multiome	304
chr15:68,650,921–68,651,400	34.7 kb	Distal (>10kb) Multiome	208
chr15:68,795,318–68,795,861	179.0 kb	Distal (>10kb) Multiome	326
chr15:68,817,340–68,819,598	201.7 kb	Distal (>10kb) Multiome	755
chr15:68,820,797–68,821,601	204.5 kb	Distal (>10kb) Multiome	618
chr15:68,875,234–68,876,172	259.3 kb	Distal (>10kb) Multiome	433

Genome Browser

Genomic view of the CORO2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.