COQ8B

coenzyme Q8B | COQ8, FLJ12229, ADCK4

This gene encodes a protein with two copies of a domain found in protein kinases. The encoded protein has a complete protein kinase catalytic domain, and a truncated domain that contains only the active and binding sites of the protein kinase domain, however, it is not known whether the protein has any kinase activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Biological processes 15 terms

ATP hydrolysis activity (GO:0016887)cerebellar Purkinje cell layer morphogenesis (GO:0021692)cytosol (GO:0005829)lipid binding (GO:0008289)mitochondrial membrane (GO:0031966)mitochondrion (GO:0005739)mitochondrion (GO:0005739)plasma membrane (GO:0005886)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein phosphorylation (GO:0006468)ubiquinone biosynthetic process (GO:0006744)ubiquinone biosynthetic process (GO:0006744)ubiquinone biosynthetic process (GO:0006744)ubiquinone biosynthetic process (GO:0006744)

Expression (TPM)

TFs regulating COQ8B 0 TFs

Transcription factors with Perturb-seq knockdown data for COQ8B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COQ8B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to COQ8B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COQ8B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:40,420,702–40,421,699	294.8 kb	Distal (>10kb) Multiome	966
chr19:40,424,783–40,426,631	290.0 kb	Distal (>10kb) Multiome	954
chr19:40,433,505–40,434,546	282.0 kb	Distal (>10kb) Multiome	791
chr19:40,442,698–40,445,144	272.7 kb	Distal (>10kb) Multiome	994
chr19:40,465,326–40,466,635	250.1 kb	Distal (>10kb) Multiome	815
chr19:40,487,850–40,488,306	227.9 kb	Distal (>10kb) Multiome	193
chr19:40,519,457–40,519,993	196.3 kb	Distal (>10kb) Multiome	222
chr19:40,528,978–40,529,879	186.7 kb	Distal (>10kb) Multiome	601
chr19:40,529,987–40,530,863	185.3 kb	Distal (>10kb) Multiome	384
chr19:40,549,036–40,549,555	166.6 kb	Distal (>10kb) Multiome	372
chr19:40,570,181–40,571,253	145.2 kb	Distal (>10kb) Multiome	598
chr19:40,576,133–40,577,495	139.1 kb	Distal (>10kb) Multiome	616
chr19:40,596,828–40,597,429	118.9 kb	Distal (>10kb) Multiome	354
chr19:40,598,094–40,598,871	117.4 kb	Distal (>10kb) Multiome	606
chr19:40,603,345–40,604,624	111.9 kb	Distal (>10kb) Multiome	889
chr19:40,604,983–40,606,597	110.2 kb	Distal (>10kb) Multiome	708
chr19:40,609,543–40,610,691	105.9 kb	Distal (>10kb) Multiome	519
chr19:40,612,884–40,615,179	102.3 kb	Distal (>10kb) Multiome	595
chr19:40,623,557–40,624,516	91.9 kb	Distal (>10kb) Multiome	454
chr19:40,634,333–40,634,959	81.4 kb	Distal (>10kb) Multiome	629
chr19:40,662,838–40,663,654	52.9 kb	Distal (>10kb) Multiome	856
chr19:40,689,888–40,691,759	25.2 kb	Distal (>10kb) Multiome	691
chr19:40,714,822–40,715,454	834 bp	At TSS Multiome	531
chr19:40,715,579–40,715,967	473 bp	At TSS	620
chr19:40,716,605–40,717,875	1.1 kb	Proximal (<10kb) Multiome	772
chr19:40,750,206–40,751,874	34.8 kb	Distal (>10kb) Multiome	989
chr19:40,777,237–40,779,173	62.3 kb	Distal (>10kb) Multiome	901
chr19:40,798,002–40,799,843	83.0 kb	Distal (>10kb) Multiome	936
chr19:40,806,580–40,807,205	91.0 kb	Distal (>10kb) Multiome	496
chr19:40,810,733–40,811,261	95.0 kb	Distal (>10kb) Multiome	115

Genome Browser

Genomic view of the COQ8B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.