This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for COQ2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COQ2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COQ2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:83,010,137–83,011,179 | 274.0 kb | Distal (>10kb) Multiome | 601 | |
| chr4:83,012,161–83,013,775 | 271.7 kb | Distal (>10kb) Multiome | 913 | |
| chr4:83,034,341–83,035,668 | 249.7 kb | Distal (>10kb) Multiome | 993 | |
| chr4:83,109,433–83,110,778 | 175.0 kb | Distal (>10kb) Multiome | 591 | |
| chr4:83,283,973–83,285,305 | 111 bp | At TSS Multiome | 879 | |
| chr4:83,334,415–83,335,295 | 50.1 kb | Distal (>10kb) Multiome | 455 | |
| chr4:83,455,343–83,456,320 | 171.1 kb | Distal (>10kb) Multiome | 983 | |
| chr4:83,484,511–83,485,585 | 200.4 kb | Distal (>10kb) Multiome | 905 | |
| chr4:83,535,410–83,536,979 | 251.6 kb | Distal (>10kb) Multiome | 690 |
Genomic view of the COQ2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.