Transcription factors with Perturb-seq knockdown data for COPG2IT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COPG2IT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COPG2IT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:130,272,868–130,273,649 | 265.6 kb | Distal (>10kb) Multiome | 220 | |
| chr7:130,440,505–130,441,456 | 97.8 kb | Distal (>10kb) Multiome | 666 | |
| chr7:130,485,879–130,487,031 | 52.6 kb | Distal (>10kb) Multiome | 696 | |
| chr7:130,575,139–130,575,863 | 36.4 kb | Distal (>10kb) Multiome | 72 | |
| chr7:130,667,922–130,669,330 | 129.7 kb | Distal (>10kb) Multiome | 738 | |
| chr7:130,733,079–130,734,492 | 194.9 kb | Distal (>10kb) Multiome | 383 |
Genomic view of the COPG2IT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.