Predicted to enable structural molecule activity. Involved in intra-Golgi vesicle-mediated transport. Part of COPI vesicle coat. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COPG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COPG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COPG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:130,069,977–130,071,012 | 598.3 kb | Distal (>10kb) Multiome HiCAR | 873 | |
| chr7:130,440,505–130,441,456 | 227.6 kb | Distal (>10kb) Multiome | 666 | |
| chr7:130,485,879–130,487,031 | 182.4 kb | Distal (>10kb) Multiome | 696 | |
| chr7:130,575,139–130,575,863 | 93.3 kb | Distal (>10kb) Multiome | 72 | |
| chr7:130,667,922–130,669,330 | 84 bp | At TSS Multiome | 738 | |
| chr7:130,733,079–130,734,492 | 65.2 kb | Distal (>10kb) Multiome | 383 |
Genomic view of the COPG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.