Predicted to be involved in sodium ion transport. Predicted to act upstream of or within cholesterol homeostasis. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COMMD9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COMMD9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COMMD9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:35,617,628–35,620,590 | 671.2 kb | Distal (>10kb) Multiome HiCAR | 755 | |
| chr11:36,048,242–36,049,115 | 240.8 kb | Distal (>10kb) Multiome | 152 | |
| chr11:36,104,718–36,105,753 | 184.3 kb | Distal (>10kb) Multiome | 417 | |
| chr11:36,109,822–36,110,461 | 179.3 kb | Distal (>10kb) Multiome | 185 | |
| chr11:36,289,232–36,289,824 | 36 bp | At TSS Multiome | 752 | |
| chr11:36,292,391–36,292,624 | 3.0 kb | Proximal (<10kb) | 144 | |
| chr11:36,375,916–36,378,030 | 88.1 kb | Distal (>10kb) Multiome | 474 | |
| chr11:36,509,026–36,510,770 | 220.8 kb | Distal (>10kb) Multiome | 984 |
Genomic view of the COMMD9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.