Predicted to be involved in sodium ion transport. Predicted to be located in extracellular region and ficolin-1-rich granule lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COMMD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COMMD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COMMD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:22,002,717–22,004,030 | 312.7 kb | Distal (>10kb) Multiome HiCAR | 868 | |
| chr10:22,016,870–22,017,923 | 298.9 kb | Distal (>10kb) Multiome | 347 | |
| chr10:22,228,979–22,229,717 | 87.0 kb | Distal (>10kb) Multiome | 978 | |
| chr10:22,243,000–22,244,484 | 72.5 kb | Distal (>10kb) Multiome | 178 | |
| chr10:22,315,958–22,317,121 | 15 bp | At TSS Multiome | 907 | |
| chr10:22,320,392–22,321,837 | 4.6 kb | Proximal (<10kb) Multiome | 685 | |
| chr10:22,321,932–22,322,482 | 5.5 kb | Proximal (<10kb) | 231 | |
| chr10:22,325,314–22,326,207 | 9.4 kb | Proximal (<10kb) Multiome | 543 | |
| chr10:22,333,913–22,337,163 | 20.3 kb | Distal (>10kb) Multiome | 477 | |
| chr10:22,340,282–22,341,538 | 24.3 kb | Distal (>10kb) Multiome | 773 | |
| chr10:22,436,581–22,437,900 | 120.6 kb | Distal (>10kb) Multiome | 649 | |
| chr10:22,513,530–22,514,377 | 197.6 kb | Distal (>10kb) Multiome | 268 |
Genomic view of the COMMD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.