Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COMMD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COMMD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COMMD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:149,618,663–149,619,621 | 133.4 kb | Distal (>10kb) Multiome | 241 | |
| chr3:149,656,829–149,659,185 | 94.4 kb | Distal (>10kb) Multiome | 974 | |
| chr3:149,716,922–149,717,701 | 35.1 kb | Distal (>10kb) Multiome | 161 | |
| chr3:149,752,004–149,753,499 | 197 bp | At TSS Multiome | 991 | |
| chr3:149,812,342–149,813,957 | 60.6 kb | Distal (>10kb) Multiome | 918 | |
| chr3:149,969,831–149,971,970 | 218.7 kb | Distal (>10kb) Multiome | 920 |
Genomic view of the COMMD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.