The protein encoded by this gene is one of two enzymes that transfers galactose moieties to hydroxylysine residues of collagen and mannose binding lectin. This gene is constitutively expressed and encodes a soluble protein that localizes to the endoplasmic reticulum. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for COLGALT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COLGALT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COLGALT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:17,266,931–17,267,755 | 288.4 kb | Distal (>10kb) Multiome | 720 | |
| chr19:17,281,537–17,283,120 | 272.8 kb | Distal (>10kb) Multiome | 669 | |
| chr19:17,292,242–17,293,049 | 263.0 kb | Distal (>10kb) Multiome | 513 | |
| chr19:17,302,721–17,303,771 | 252.2 kb | Distal (>10kb) Multiome | 636 | |
| chr19:17,305,286–17,306,514 | 250.0 kb | Distal (>10kb) Multiome | 947 | |
| chr19:17,309,159–17,310,151 | 246.1 kb | Distal (>10kb) Multiome | 741 | |
| chr19:17,327,532–17,329,548 | 227.7 kb | Distal (>10kb) Multiome | 370 | |
| chr19:17,334,287–17,335,052 | 220.8 kb | Distal (>10kb) Multiome | 870 | |
| chr19:17,336,574–17,338,240 | 218.2 kb | Distal (>10kb) Multiome | 924 | |
| chr19:17,340,311–17,341,226 | 215.0 kb | Distal (>10kb) Multiome | 419 | |
| chr19:17,390,414–17,391,521 | 164.5 kb | Distal (>10kb) Multiome | 615 | |
| chr19:17,394,998–17,395,433 | 160.4 kb | Distal (>10kb) Multiome | 403 | |
| chr19:17,398,863–17,399,537 | 156.4 kb | Distal (>10kb) Multiome | 132 | |
| chr19:17,403,087–17,404,355 | 152.1 kb | Distal (>10kb) Multiome | 211 | |
| chr19:17,419,503–17,420,821 | 135.7 kb | Distal (>10kb) Multiome | 869 | |
| chr19:17,424,865–17,425,411 | 130.5 kb | Distal (>10kb) Multiome | 328 | |
| chr19:17,448,174–17,448,841 | 107.0 kb | Distal (>10kb) Multiome | 392 | |
| chr19:17,468,858–17,470,905 | 85.5 kb | Distal (>10kb) Multiome | 743 | |
| chr19:17,488,739–17,489,689 | 66.5 kb | Distal (>10kb) Multiome | 381 | |
| chr19:17,511,113–17,512,592 | 44.1 kb | Distal (>10kb) Multiome | 1021 | |
| chr19:17,538,878–17,540,353 | 15.9 kb | Distal (>10kb) Multiome | 725 | |
| chr19:17,555,194–17,556,523 | 84 bp | At TSS Multiome | 713 | |
| chr19:17,576,463–17,577,455 | 21.3 kb | Distal (>10kb) Multiome | 236 | |
| chr19:17,579,580–17,580,242 | 24.4 kb | Distal (>10kb) Multiome | 281 | |
| chr19:17,605,468–17,607,009 | 50.5 kb | Distal (>10kb) Multiome | 1030 | |
| chr19:17,686,280–17,688,656 | 131.1 kb | Distal (>10kb) Multiome | 586 | |
| chr19:17,719,144–17,719,957 | 163.8 kb | Distal (>10kb) Multiome | 585 | |
| chr19:17,747,227–17,748,170 | 192.0 kb | Distal (>10kb) Multiome | 503 | |
| chr19:17,762,487–17,762,985 | 207.1 kb | Distal (>10kb) Multiome | 199 | |
| chr19:17,778,112–17,778,869 | 222.7 kb | Distal (>10kb) Multiome | 311 | |
| chr19:17,794,880–17,795,385 | 239.5 kb | Distal (>10kb) Multiome | 465 | |
| chr19:17,829,926–17,831,824 | 275.3 kb | Distal (>10kb) Multiome | 466 | |
| chr19:17,841,205–17,843,221 | 286.5 kb | Distal (>10kb) Multiome | 545 | |
| chr19:17,847,546–17,848,187 | 292.1 kb | Distal (>10kb) Multiome | 437 |
Genomic view of the COLGALT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.