This gene encodes a protein that contains WH2 domains (WASP, Wiskott-Aldrich syndrome protein, homology domain-2) that interact with actin. The encoded actin regulator protein is required for growth and assembly of brush border microvilli that play a role in maintaining intestinal homeostasis. A similar protein in mouse functions in midbrain neural tube closure. A pseudogene of this gene is located on chromosome X. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for COBL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COBL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COBL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:51,080,753–51,081,550 | 235.8 kb | Distal (>10kb) Multiome | 203 | |
| chr7:51,121,838–51,122,515 | 194.6 kb | Distal (>10kb) Multiome | 173 | |
| chr7:51,141,299–51,142,104 | 175.1 kb | Distal (>10kb) Multiome | 121 | |
| chr7:51,307,375–51,307,554 | 9.3 kb | Proximal (<10kb) | 1 | |
| chr7:51,307,691–51,308,183 | 8.6 kb | Proximal (<10kb) | 21 | |
| chr7:51,308,296–51,308,939 | 7.9 kb | Proximal (<10kb) | 36 | |
| chr7:51,309,843–51,310,086 | 6.7 kb | Proximal (<10kb) | 13 | |
| chr7:51,310,973–51,311,698 | 5.1 kb | Proximal (<10kb) | 68 | |
| chr7:51,315,400–51,317,810 | 126 bp | At TSS Multiome | 673 | |
| chr7:51,325,356–51,325,601 | 8.5 kb | Proximal (<10kb) | 42 | |
| chr7:51,326,603–51,327,801 | 10.6 kb | Distal (>10kb) Multiome | 297 |
Genomic view of the COBL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.