This gene encodes a protein that localizes to the mitochondria, where it stimulates the release of cytochrome c, thereby promoting programmed cell death. Mutations in this gene have been found in individuals with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Transcription factors with Perturb-seq knockdown data for COA8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COA8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COA8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:103,333,053–103,335,386 | 228.9 kb | Distal (>10kb) Multiome | 1004 | |
| chr14:103,384,755–103,386,021 | 177.7 kb | Distal (>10kb) Multiome | 863 | |
| chr14:103,456,058–103,456,564 | 106.7 kb | Distal (>10kb) Multiome | 49 | |
| chr14:103,518,427–103,519,043 | 44.2 kb | Distal (>10kb) Multiome | 404 | |
| chr14:103,520,443–103,523,552 | 40.1 kb | Distal (>10kb) Multiome | 756 | |
| chr14:103,528,671–103,529,619 | 33.8 kb | Distal (>10kb) Multiome | 726 | |
| chr14:103,561,982–103,563,356 | 159 bp | At TSS Multiome | 781 | |
| chr14:103,628,110–103,630,126 | 66.2 kb | Distal (>10kb) Multiome | 909 | |
| chr14:103,715,029–103,716,504 | 152.6 kb | Distal (>10kb) Multiome | 709 | |
| chr14:103,846,809–103,848,686 | 284.7 kb | Distal (>10kb) Multiome | 711 | |
| chr14:103,855,145–103,855,758 | 292.6 kb | Distal (>10kb) Multiome | 418 |
Genomic view of the COA8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.