Transcription factors with Perturb-seq knockdown data for CNTNAP5-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNTNAP5-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNTNAP5-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:124,024,525–124,026,034 | 44 bp | At TSS Multiome | 392 | |
| chr2:124,027,020–124,027,687 | 1.8 kb | Proximal (<10kb) | 192 | |
| chr2:124,068,992–124,069,837 | 44.4 kb | Distal (>10kb) Multiome | 93 |
Genomic view of the CNTNAP5-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.